BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Novel Molecular Mechanism of APE2 in Mitochondrial Genomic Sta
 bility
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260808T154114Z
UID:tag:localist.com\,2008:EventInstance_52427078342993
DTSTART:20260408T190000Z
DTEND:20260408T200000Z
DESCRIPTION:Candidate Name: Garrett Driscoll\nProgram: Biology​​​​
 ​​​\nCommittee Chair: Dr. Shan Yan​​​​​​​\nCommittee M
 embers: Dr. Christine Richardson\, Dr. Kausik Chakbrabarti\, Dr. Junya Tom
 ida\, Dr. In Hong Yang\nAbstract:\n\nCisplatin-associated acute kidney inj
 ury (C-AKI) is a significant challenge in cancer treatment\, closely tied 
 to mitochondrial problems. Since mitochondria have a limited ability to re
 pair their DNA\, damage caused by cisplatin to mitochondrial DNA (mtDNA) c
 an be especially harmful to kidney tubular cells. In our study with human 
 kidney proximal tubule cells (HK2)\, we discovered that apurinic/apyrimidi
 nic endonuclease 2 (APE2) plays a crucial role in responding to this type 
 of damage. We observed that cisplatin increases APE2 levels and fosters a 
 connection between APE2 and DNA-dependent protein kinase catalytic subunit
  (DNA-PKcs)\, as shown by proximity ligation assay. Moreover\, we found th
 at DNA-PKcs signaling is linked to the activation of mitochondrial fission
  proteins\, such as FIS1 and DRP1\, which aligns with the observed mitocho
 ndrial fragmentation following mtDNA damage. Interestingly\, cisplatin exp
 osure also causes damaged mtDNA to be released into the cytosol\, activati
 ng the cGAS-STING pathway. Importantly\, reducing APE2 levels through knoc
 kdown experiments decreased mtDNA release\, indicating that APE2 is involv
 ed in signaling mitochondrial stress caused by cisplatin. In summary\, our
  research highlights APE2 as a key player connecting cisplatin-induced mtD
 NA damage with mitochondrial fission and immune responses in kidney cells\
 , offering new insights into the mechanisms behind these processes C-AKI.
GEO:35.307112;-80.735737
LOCATION:Woodward\, 244
SUMMARY:Novel Molecular Mechanism of APE2 in Mitochondrial Genomic Stabilit
 y
URL;VALUE=URI:https://campusevents.charlotte.edu/event/novel-molecular-mech
 anism
CATEGORIES:Academic Calendar
CATEGORIES:Public
END:VEVENT
END:VCALENDAR