BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Influence of Secondary Structure and Modifications in Sequence
 s During Nucleic Acid Readthrough: Analysis\, Prediction\, and Application
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260807T183349Z
UID:tag:localist.com\,2008:EventInstance_51213800270924
DTSTART:20251111T180000Z
DTEND:20251111T190000Z
DESCRIPTION:Candidate Name: Katie Jensen\nProgram: Bioinformatics and Compu
 tational Biology​​​​​​​\nCommittee Chairs: Dr. Jennifer Well
 er and Dr. Jessica Roseberry​​​​​​​\nCommittee Members: Dr. 
 Cynthia Gibas\, Dr. Kristen Funk\, Dr. Anthony Fodor\, Dr. Jun-tao Guo\, D
 r. Shan Yan\nAbstract:\n\nThere is a need for high-throughput assessment a
 nd prediction of nucleic acid secondary structure and base modifications\,
  and a better understanding of how they affect one another in specific con
 ditions such as human disease. Furthermore\, there is a need to differenti
 ate among structure-related\, chemically modified\, or true variant baseca
 lls in genomic and transcriptomic sequencing outcomes.\n\nTo address these
  needs\, structured DNA templates were first designed and constructed\, th
 en sequenced on the third-generation ONT sequencing platform. Distinct pat
 terns by secondary structure type were revealed\, showing promise for appl
 ication to sequencing projects which rely heavily on precise nucleobase as
 signments.  Then\, next-generation Illumina RNA sequencing data from post-
 mortem brain tissue of an aged cohort\, including Alzheimer’s disease pa
 tients\, was assessed for epitranscriptomic modifications using a novel ap
 proach. Application of this custom methodology uncovered a subset of modif
 ications with important implications for Alzheimer’s disease and aging m
 echanisms in the brain. These modifications were further assessed for thei
 r proximity to and/or predicted effect on structured regions in the RNA tr
 anscripts and how this may play a role in Alzheimer’s disease.
GEO:35.312772;-80.741969
LOCATION:Bioinformatics\, 301
SUMMARY:Influence of Secondary Structure and Modifications in Sequences Dur
 ing Nucleic Acid Readthrough: Analysis\, Prediction\, and Application
URL;VALUE=URI:https://campusevents.charlotte.edu/event/Influence-of-Seconda
 ry-Structure-and-Modifications-in-Sequences-During-Nucleic-Acid-Readthroug
 h-Analysis-Prediction-and-Application
CATEGORIES:Academic Calendar
CATEGORIES:Public
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